Linus Pauling, la Fundación Rockefeller y el nacimiento de la medicina molecular

Francisco Javier Serrano-Bosquet

Resumen


L. Pauling, the Rockefeller Foundation and the birth of molecular biology

The development of medicine was made possible thanks to the advances produced in chemistry. Research on sickle-cell anemia by Linus Pauling and his team is a clear example. The understanding of this disease in molecular terms was made possible by the transference of knowledge, methodologies and tools from the chemical and biological disciplines. This paper analyzed the process under which molecular medicine was developed, the frameworks and guidelines that dictate its realization, and their epistemological and ontological implications. We also analyzed the work that Warren Weaver and Robert S. Morrison did in the Rockefeller Foundation, which turned essential in such process.

Key words. Sickle cell anemia, Experimental Biology Program, Rockefeller Foundation, history of medicine, Linus Pauling, molecular medicine, biological reductionism, methodological transferences.


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Referencias


Anson, M., & Mirsky, A. (1929), “Protein coagulation and its reversal,” Journal of General Physiology 13: 121–132.

Ayala, F. (1983), “Introducción,” en F. Ayala, & T. Dobshansky, Estudios sobre la filosofía de la biología, Barcelona: Ariel, pp. 9-29.

Brailovsky, C., & Centeno, A. (2012), “Algunas tendencias actuales en educación médica,” Revista de Docencia Universitaria 10: 23-33.

Büttner, J. (1994, 31-diciembre), “Clinical chemistry as scientific discipline: Historical perspectives,” Clinica Chimica Acta 232(1-2): 1-9.

Caponi, G. (julio-diciembre de 2004), “El reduccionismo en la biología contemporánea,” Signos Filosóficos VI(12): 33-62.

Claros, G. (Junio de 2003), Aproximación histórica a la biología molecular. Panace@ IV(12). Obtenido de http://www.medtrad.org/panacea/IndiceGeneral /n12_tribuna_GClaros.pdf

Crick, F., & Cochran, W. (1952), “Evidence for the Pauling-Corey alphahelix in syntetic polypeptides,” Nature 169: 234-235.

Dobzhansky, T. (1983), “Comentarios preliminares,” en F. Ayala, & T. Dobzhansky, Estudios sobre la filosofía de la biología. Barcelona: Ariel, pp. 23-24.

Hager, T. (1998), Linus Pauling and the Chemistry of Life. New York: Oxford University Press.

Itano, H. (1951), “A third abnormal hemoglobin associated with hereditary hemolytic anemia,” Proceedings of the National Academy of Sciences 37: 775-784.

Itano, H., & Neel, J. (1950), “A new inherited abnormality of human hemoglobin,” Proceedings of the National Academy of Sciences 36: 613-617.

Itano, H., & Pauling, L. (1949), “A rapid diagnostic test for sickle cell anemia,” Blood: The Journal of Hematology IV(1): 66-68.

Kohler, R. (1976), “The management of science: the experience of Warren Weaver and the Rockefeller Foundation Programme in Molecular Biology,” Minerva 14: 279-306.

López-Muñoz, F., Ucha-Udabe, R., & Alamo, C. (2005), “The history of barbiturates a century after their clinical introduction,” Neuropsychiatric Disease and Treatment 1(4): 329–343.

Marsh, R., Branson, H., & Pauling, L. (1955), “An investigation of the structure of silk fibroin,” Biochimica Et Biophysica Acta 16: 1-34.

Mayr, E. (1988), Towars a New Philosophy of Biology. Cambridge: Harvard University Press.

Mead, C., & Hager, T. (edits.) (2001), Linus Pauling: Scientist and Peacemaker. Corvallis, Oregon: Oregon State University Press.

Mirsky, A., & Pauling, L. (1936), “On The structure of native, denatured, and coagulated proteins,” Proceedings of the National Academy of Science 22(7): 439-447.

Morgan, G. J. (1998), “Emile Zuckerkandl, Linus Pauling, and the molecular evolutionary clock, 1959-1965,” Journal of the History of Biology 31: 155-178.

Morinson, R. S. (1956), “Biological and medical research,” in R. Foundation, The Rockefeller Foundation, Annual Report 1955 , New York: Rockefeller Foundation, pp. 44-52.

Neel, J. (1949), “The inheritance of sickle cell anemia,” Science, 110 (2846), 64-66.

Olby, R. (1974), The Path to the Double Helix. Londres: Macmillan.

Pauling, L. (1931), “The nature of the chemical bond. Application of results obtained from the quantum mechanics and from theory of paramagnetic susceptibility to the structure of molecules,” Journal American Chemistry Society 53: 1367-1400.

Pauling, L. (1937), “The significance of structural chemistry,” George Fisher Baker Lectureship. Ithaca, New York: Cornell University.

Pauling, L. (1939), The Nature of the Chemical Bond and the Structure of Molecules and Crystals: an Introduction to Modern Structural Chemistry. Ithaca, Nueva York: Cornell University Press.

Pauling, L. (3 de March de 1948), “Letter from Linus Pauling to Robert Corey,” Pasadena, California: Oregon State University.

Pauling, L. (1948), “The nature of forces between large molecules of biological interest,” Proceedings of the Royal Institution of Great Britain 34: 181-187.

Pauling, L. (1949), “Structural chemistry in relation to biology and medicine”. Second Bicentennial Science Lecture of The City College Chemistry Alumni Association 1(1): 4-7. Baskerville Chemical Journal 1(1): 4-7.

Pauling, L. (1959), “Molecular disease”, Science 110(2865): 543-548.

Pauling, L. (1960), “Interview with Linus Pauling,” Pauling’s Interest in Sickle Cell Anemia. (N. F. Canada, Entrevistador)

Pauling, L. (1968), “Orthomolecular psychiatry: varying the concentrations of substances normally present in the human body may control mental disease,” Science 160: 265-271.

Pauling, L. (1970), “Fifty years of progress in structural chemistry and molecular biology,” Daedalus 99: 988-1014.

Pauling, L., & Campbell, D. (1942), “The manufacture of antibodies in vitro,” Journal of Experimental Medicine 76: 211-220.

Pauling, L., & Corey, R. (1950), “Two hydrogen-bonded spiral configurations of the polypeptide chain,” Journal of the American Chemical Society 72: 5349.

Pauling, L., Campbell, D., & Pressman, D. (1941), “Serological reactions with simple substances containing two or more haptenic groups,” Proceedings of the National Academy of Science 27: 125-128.

Pauling, L., Corey, R., & Branson, H. (1951), “The structure of proteins: two hydrogen-bonded helical configurations of the polypeptide chain”. Proceedings of the National Academy of Science 37: 205-210.

Pauling, L., Itano, H. A., Singer, S. J., & Wells, I. C. (1949, 25-Noviembre). “Sickle cell anemia, a molecular disease,” Adress to the American Ontopsychiatric Association, San Francisco March 29. http://profiles.nlm.nih.gob/ps/access/MMBBKW.pdf.

Pauling, L. (1959b), “Molecular disease”, American Journal of Ontopsychiatry 29(4): 684-687.

Pauling, L., Pressman, D., Campbell, D., Ikeda, C., & Ikawa, M. (1942), “The serological properties of simple substances. i. precipitation reactions between antibodies and substances containing two or more haptenic groups”. Journal of the American Chemical Society 64: 2994-3003.

Rosenfield, R. (ed.), (1999), Biographies and Other Essays on the History of Clinical Chemistry. (L. Rosenfeld, Ed.) Washington: American Association for Clinical Chemistry.

Serafini, A. (1989), Linus Pauling. A Man and his Science. Lincoln (NE): Excel Press.

Serrano-Bosquet, F. J. (2006), Biología molecular. Cuestiones e implicaciones filosóficas. México: Limusa.

Serrano-Bosquet, F. J. (2009), Ciencia, realidad y método en la obra de Linus Pauling. http://eprints.ucm.es/9746/

Serrano-Bosquet, F. J. (2009b), “Linus Pauling: molecular disease and the origins of molecular biology,” in J. L. González Recio, Philosophical Essays on Physics and Biology. Hildesheim-Zürich-New York: Georg Olms, pp.151-157.

Serrano-Bosquet, F. J. (2011), “El reduccionismo fisicalista en la obra biológica de Linus Pauling”, Thémata. Revista de Filosofía 44.

Serrano-Bosquet, F., & Caponi, G. (2014), “Warren Weaver: Valores cognitivos y perspectiva epistemológica del Experimental Biology Program de la Fundación Rockefeller,” Scientiae Studia 12 (2 ),

Taliaferro, W., & Huck, J. (1923), “The inheritance of sickle-cell anaemia in man,” Genetics 8 (6): 594-598.

Weaver, W. (1959), “A quarter century in the natural sciences,” in R. Foundation, Anual Report 1958: 1-122.

Williams, D. A., Foye, W. O., & Lemke, T. L. (2002), Foyess Principles of Medical Chemistry. (D. Troy, ed.) Baltimore: Lippintcott Williams & Wilkins.

Zuckerkandl, E., & Pauling, L. (1962), Molecular Disease, Evolution and Genetic Heterogeneity. NY: Academic Press.

Zuckerkandl, E., & Pauling, L. (1965), “Evolutionary divergence and convergence in proteins,” in V. y. Bryson, Evolving Genes and Proteins. NY: Academic Press.


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