Crear recuerdos perdurables: acordarse de lo significativo
Resumen
Making lasting memories: remembering the significant
Although forgetting is the common fate of most of our experiences, much evidence indicates that emotional arousal enhances the storage of memories, thus serving to create, selectively, lasting memories of our more important experiences. The neurobiological systems mediating emotional arousal and memory are very closely linked. The adrenal stress hormones epinephrine and corticosterone released by emotional arousal regulate the consolidation of long-term memory. The amygdala plays a critical role in mediating these stress hormone influences. The release of norepinephrine in the amygdala and the activation of noradrenergic receptors are essential for stress hormone-induced memory enhancement. The findings of both animal and human studies provide compelling evidence that stress-induced activation of the amygdala and its interactions with other brain regions involved in processing memory play a critical role in ensuring that emotionally significant experiences are well-remembered. Recent research has determined that some human subjects have highly superior autobiographic memory of their daily experiences and that there are structural differences in the brains of these subjects compared with the brains of subjects who do not have such memory. Understanding of neurobiological bases of such exceptional memory may provide additional insights into the processes underlying the selectivity of memory.
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Akirav, I., Richter-Levin, G. (1999), “Biphasic modulation of hippocampal plasticity by behavioral stress and basolateral amygdala stimulation in the rat,” J Neurosci 19(23): 10530–10535.
Anderson, A. K., Yamaguchi, Y., Grabski, W., Lacka, D. (2006), “Emotional memories are not all created equal: Evidence for selective memory enhancement,” Learn Mem 13(6): 711–718.
Arai, T., Watanabe, T., Nagaro, T., Matsuo, S. (1981), “Blood-brain barrier impairment after cardiac resuscitation,” Crit Care Med 9(6): 444–448.
Bacon, F. (2000). The New Organon, eds. Jardine L, Silverthorne. M Cambridge, United Kingdom: Cambridge University Press.
Bass, D. I., Partain, K. N., Manns, J. R. (2012). “Event-speci!c enhancement of memory via brief electrical stimulation to the basolateral complex of the amygdala in rats,” Behav Neurosci 126(1): 204–208.
Bergado, J. A., Rojas, Y., Capdevila, V., González, O., Almaguer-Melian, W. (2006), “Stimulation of the basolateral amygdala improves the acquisition of a motor skill,” Restor Neurol Neurosci 24(2): 115–121.
Berlau, D. J., McGaugh, J. L. (2006), “Enhancement of extinction memory consolidation: The role of the noradrenergic and GABAergic systems within the basolateral amygdala,” Neurobiol Learn Mem 86(2): 123–132.
Bernecker, S. (2010), Memory. Oxford: Oxford University Press.
Bohannon, J. N., 3rd (1988), “Flashbulb memories for the space shuttle disaster: A tale of two theories,” Cognition 29(2): 179–196.
Borges, J. L. (1944), “Funes el memorioso,” en A. Kerrigan, trans A. Bonner (ed.) (1962) Ficciones, New York: Grove Press.
Breen, R. A., McGaugh, J. L. (1961), “Facilitation of maze learning with post-trial injections of picrotoxin,” J Comp Physiol Psychol 54: 498–501.
Brown, R., Kulik, J. (1977), “Flashbulb memories,” Cognition 5(1): 73–99.
Cahill, L., Alkire, M. T. (2003), “Epinephrine enhancement of human memory consolidation: Interaction with arousal at encoding,” Neurobiol Learn Mem 79(2): 194–198.
Cahill, L., et al. (1996), “Amygdala activity at encoding correlated with long-term, free recall of emotional information,” Proc Natl Acad Sci USA 93(15): 8016– 8021.
Cahill, L., Gorski, L., Le, K. (2003), “Enhanced human memory consolidation with postlearning stress: Interaction with the degree of arousal at encoding,” Learn Mem 10(4): 270–274.
Cahill, L., Prins, B., Weber, M., McGaugh, J. L. (1994), “β-adrenergic activation and memory for emotional events,” Nature 371(6499): 702–704.
Canli, T., Desmond, J. E., Zhao, Z., Gabrieli, J. D. (2002), “Sex differences in the neural basis of emotional memories,” Proc Natl Acad Sci USA 99(16): 10789– 10794.
Canli, T., Zhao, Z., Brewer, J., Gabrieli, J. D., Cahill, L. (2000), “Event-related activation in the human amygdala associates with later memory for individual emotional experience,” J Neurosci 20(19): RC99.
Chavez, C. M., McGaugh, J. L., Weinberger, N. M. (2009), “The basolateral amygdala modulates specific sensory memory representations in the cerebral cortex,” Neurobiol Learn Mem 91(4): 382–392.
Chavez, C. M., McGaugh, J. L., Weinberger, N. M. (2012), “Amygdala strengthening of cortical memory representations,” in B. Ferry (ed.), The Amygdala—A Discrete Multitasking Manager. Rijeka, Croatia: In Tech.
Chavez, C. M., McGaugh, J. L., Weinberger, N. M. (2013), “Activation of the basolateral amygdala induces long-term enhancement of specific memory representations in the cerebral cortex,” Neurobiol Learn Mem 101: 8–18.
Christianson, S-A. (1992), Handbook of Emotion and Memory: Current Research and Theory. Hillsdale, NJ: Lawrence Erlbaum Associates.
Clark, K. B., et al. (1998), “Post-training electrical stimulation of vagal afferents with concomitant vagal efferent inactivation enhances memory storage processes in the rat,” Neurobiol Learn Mem 70(3): 364–373.
Clark, K. B., Naritoku, D. K., Smith, D. C., Browning, R. A., Jensen, R. A. (1999), “Enhanced recognition memory following vagus nerve stimulation in human subjects,” Nat Neurosci 2(1): 94–98.
Clayton, E. C., Williams, C. L. (2000), “Adrenergic activation of the nucleus tractus solitaries potentiates amygdala norepinephrine release and enhances retention performance in emotionally arousing and spatial memory tasks,” Behav Brain Res 112(1-2): 151–158.
Conway, M. A. (1995), Flashbulb Memories. England: Erlbaum, Brighton.
Conway, M. A., et al. (1994), “The formation of flashbulb memories,” Mem Cognit 22(3): 326–343.
Craik, F. I. M., Lockhart, R. S. (1972), “Levels of processing: A framework for memory research,” J Verbal Learn and Verbal Behav 11: 671–684.
Dolcos, F., LaBar, K. S., Cabeza, R. (2004), “Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events,” Neuron 42(5): 855–863.
Dornelles, A., et al. (2007), “Adrenergic enhancement of consolidation of object recognition memory,” Neurobiol Learn Mem 88(1): 137–142.
Dringenberg, H. C., Kuo, M. C., Tomaszek, S. (2004), “Stabilization of thalamocortical longterm potentiation by the amygdala: Cholinergic and transcription-dependent mechanisms,” Eur J Neurosci 20(2): 557–565.
Dringenberg, H. C., Saber, A. J., Cahill, L. (2001), “Enhanced frontal cortex activation in rats by convergent amygdaloid and noxious sensory signals,” Neuroreport 12(11): 2395–2398.
Dringenberg, H. C., Vanderwolf, C. H. (1996), “Cholinergic activation of the electrocorticogram: An amygdaloid activating system,” Exp Brain Res 108(2): 285–296.
Duncan, C. P. (1949), “The retroactive effect of electroshock on learning,” J Comp Physiol Psychol 42(1): 32–44.
Ebbinghaus, H. (1885), Uber das Gedachtnis. Leipzig, Germany: Drucker and Humblat.
Eichenbaum, H., Stewart, C., Morris, R. G. M. (1990), “Hippocampal representation in place learning,” J Neurosci 10(11): 3531–3542.
Gallagher, M., Kapp, B. S., Pascoe, J. P., Rapp, P. R. (1981), “A neuropharmacology of amygdaloid systems which contribute to learning and memory,” en Y. Ben-Ari (ed.), The Amygdaloid Complex. Amsterdam: Elsevier. pp 343–354.
Galvez, R., Mesches, M. H., McGaugh, J. L. (1996), “Norepinephrine release in the amygdala in response to footshock stimulation,” Neurobiol Learn Mem 66(3): 253–257.
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