The concept of pre-embryonic genes

Ronald Lee Hancock

Resumen


The evolutionary origin of pre-embryonic genes can be conceived as having arisen from pre-embryonic type organisms such as yeast. Control mechanisms of yeast were explored conceptually emphasizing heterochromatization and epigenetic mechanisms. It was argued, by using the carcinogeninduced tRNA methylase system in liver cells, that experiments showing a similar gene-induced activity in yeasts, could only be explained if both were sets being controlled by the same or similar mechanisms. By virtue of the fact that carcinogens induce embryonic gene activities, one can then say that carcinogens induce a similar set of pre-embryonic genes in yeasts.

 

Key words: Embryonic genes, evolution, yeast, tRNA methylase activity, carcinogens, Heterochromatin spread, histone code, Ubiquitin-conjugation enzymes, Ethionine, enhancer mechanisms.

 


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Referencias


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Hancock, R.L., Forrester, P.E., Lorscheider, F.L., Lai, P.C.W. and Hay, D.M. (1976), “Ethionine induced activation of embryonic genes,” in Fishman, W. and Sell, S. (eds.), Onco-Developmental Gene Expression. N.Y.: Academic Press, pp. 257-251.

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