¿Hasta qué punto son específicos los trastornos específicos del lenguaje? Implicaciones para una caracterización biológica de la facultad lingüística humana

Antonio Benítez Burraco

Resumen


To what point are specific the specific language impairments? Some biological characterization of the human linguistic faculty

An increasing corpus of clinical, neuroanatomical, neurophysiological, and genetic evidences seems to put into question the idiosyncratic nature of the so-called specific language impairments. Methodological caveats could be in part responsible for some of the problems that arise when trying to precisely characterize and distinctively define this kind of cognitive disorders. However, those evidences also seem to demand a thorough re-examination of the conventional description of how the “language organ” is structured, and how it develops and works. A main conclusion here will be that the “language organ” emerges during ontogeny as a result of an innate programme (genetically encoded to some extent), which, nevertheless, is always conditioned by the molecular and the ontogenetic background of the organism, and also by the environment in which the subject lives. Inside this “organ” different neuronal structures jointly work in order to properly process linguistic stimuli, though each of these components are simultaneously able to compute different types of inputs.

 

Key words: Aphasia, comorbidity, dyslexia, environment, genetic programme, language, linguistic ontogeny, modularity, molecular biology, SLI.


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Referencias


Almasy, I. y Blangero, J. (2001), “Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design”, Am. J. Med. Genet. 105: 42-44.

American Psychiatric Association (1994), Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Washington: American Psychiatric Association.

Anderlid, B. M., Schoumans, J., Hallqvist, A., Stahl, Y., Wallin, A., Blennow, E. y Nordenskjold, M. (2003), “Cryptic subtelomeric 6p deletion in a girl with congenital malformations and severe language impairment”, Eur. J. Hum. Genet. 11: 89-92.

Anderson, S. R. (1993), “Linguistic expression and its relation to modality”, in G. R Coulter (ed.), Phonetics and Phonology 3: Current Issues in ASL Phonology. San Diego: Academic.

Anderson, S. R. y Lightfoot, D. W. (2000), “The human language faculty as an organ”, Annu. Rev. Physiol. 62: 697-722.

Angold, A., Costello, E. J. y Erkanli, A. (1999), “Comorbidity”, J. Child Psychol. Psychiatry 40: 57-87.

Ansink, B. J. J., Sarphatie, H. y Van Dongen, H. R. (1989), “The Landau-Kleffner syndrome: case report and theoretical considerations”, Neuropediatrics 20: 170-172.

Antonell, A., del Campo, M., Flores, R.,Campuzano, V. y Pérez-Jurado, L. A. (2006), “Síndrome de Williams: aspectos clínicos y bases moleculares”, Rev. Neurol. 42: S69-S75.

Avital, E. y Jablonka, E. (2000), Animal Traditions. Behavioural Inheritance in Evolution. Cambridge: Cambridge University Press.

Bellugi, U., Klima, E. S. y Wang, P. P. (1996), “Cognitive and neural development: clues from genetically based syndromes”, in D. Magnussen (ed.), The Life-Span Development of Individuals: Behavioral, Neurobiological, and Psychosocial Perspectives. A Synthesis. Cambridge: Cambridge University Press, pp. 223-243.

Bellugi, U., Losh, M., Reilly, J y Anderson, D. (1998), Excessive Use of Linguistically Encoded Affect: Stories from Young Children with Williams Syndrome (Technical Report CND-9801), University of California: Center for Research in Language, Project in Cognitive and Neural Development.

Bellugi, U., Lichtenberger, L., Mills, D., Galaburda, A. y Korenberg, J. R. (1999), “Bridging cognition, the brain and molecular genetics: evidence from Williams syndrome”, Trends Neurosci. 22: 197-207.

Belton, E., Salmond, C. H., Watkins, K. E., Vargha-Khadem, F. y Gadian, D. G. (2003), “Bilateral brain abnormalities associated with dominantly inherited verbal and orofacial dyspraxia”, Hum. Brain Mapp. 18: 194-200.

Benítez-Burraco, A. (2005), “FOXP2: del trastorno específico a la biología molecular del lenguaje. I. Aspectos etiológicos, neuroanatómicos, neurofisiológicos y moleculares”, Rev. Neurol. 40: 671-682.

Benítez-Burraco, A. (2007), “Bases moleculares de la dislexia”, Rev. Neurol. 45: 491-502.

Benítez-Burraco, A. (en prensa), “La cuestión de lo innato en la adquisición del lenguaje”, RSEL.

Bickerton, D. (1999), “How to acquire language without positive evidence: what acquisitionists can learn from creoles”, in M. DeGraff (ed.), Language Creation and Change: Creolization, Diachrony and Development. Cambridge: MIT Press.

Billard, C., Toutain, A., Loisel, M.-L., Gillet, P., Barthez, M.-A. y Maheut, J. (1994), “Genetic basis of developmental dysphasia: report of eleven familial cases in six families”, Genet. Counsel. 5: 22-33.

Bishop, D. V. M. (2001a), “Genetic influences on language impairment and literacy problems in child”, J. Child Psychol. Psychiatry 42: 189-198.

Bishop, D. V. M. (2001b), “Genetic and environmental risks for specific language impairment in children”, Philos. Trans. R. Soc. Lond., B, Biol. Sci. 356: 369-380.

Bishop, D. V. M. (2002), “The role of genes in the etiology of specific language impairment”, J. Commun. Disord. 35: 311-328.

Bishop, D. V. M. y Leonard, L. (2001), Speech and Language Impairments in Children: Causes, Characteristics, Intervention and Outcome. Oxford: Oxford: Psychology Press.

Bishop, D. V. M., North, T. y Donlan, C. (1995), “Genetic basis for specific language impairment: evidence from a twin study”, Dev. Med. Child Neurol. 37: 56-71.

Bishop, D. V. M., Bishop, S. J., Bright, P., James, C., Delaney, T. y Tallal, P. (1999), “Different origin of auditory and phonological processing problems in children with language impairment: evidence from a twin study”, J. Speech Lang. Hear. Res. 42: 155-68.

Bonaglia, M. C., Giorda, R., Borgatti, R., Felisari, G., Gagliardi, C., Selicorni, A. y Zuffardi, O. (2001), “Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome”, Am. J. Hum. Genet. 69: 261-268.

Bonaglia, M. C., Giorda, R., Mani, E., Aceti, G., Anderlid, B.-M., Baroncini, A., Pramparo, T. y Zuffardi, O. (2006), “Identification of a recurrent breakpoint within the SHANK3 gene in the 22q13.3 deletion syndrome”, J. Med. Genet. 43: 822-828.

Bosch, L. y Sebastián-Galles, N. (1997), “Native-language recognition abilities in 4-month-old infants from monolingual and bilingual environments”, Cognition 65: 33-69.

Boyar, F. Z., Whitney, M. M., Lossie, A. C., Gray, B. A., Keller, K. L., Stalker, H. J., Zori, R. T., Geffken, G., Mutch, J., Edge, P. J., Voeller, K. S., Williams, C. A. y Driscoll, D. J. (2001), “A family with a grandmaternally derived interstitial duplication of proximal 15q”, Clin. Genet. 60: 421-430.

Brzustowicz, L. M. (1996), “Looking for language genes: lessons from complex disorder studies”, in M. Rice y N. J. Mahwah (eds.), Towards a Genetics of Language. New Jersey: Erlbaum Associates, pp. 3-25.

Chomsky, N. A. (1980), Rules and Representations. Oxford: Basil Blackwell.

Chomsky, N. A. (1986), Knowledge of Language: Its Nature, Origin and Use. New York: Prager.

Chomsky, N. A. (1995), The Minimalist Program. Cambridge: MIT Press.

Comings, D. E., Wu, S., Chiu, C., Muhleman, D. y Sverd, J. (1996), “Studies of the c-Harvey-Ras gene in psychiatric disorders”, Psychiatry Res. 63: 25-32.

Crain, S. (1991), “Language acquisition in the absence of experience”, Behav. Brain Sci. 14: 597-650.

Dehaene-Lambertz, G. y Houston, D. (1998), “Faster orientation latency toward native language in two-month-old infants”, Lang. Speech 41: 21-43

Dronkers, N. F., Redfern, B. B. y Knight, R. T. (2000), “The neural architecture of language disorders”, in M. S. Gazzaniga (ed.), The New Cognitive Neurosciences. Cambridge: MIT Press, pp. 949-961.

Felsenfeld, S. y Plomin, R. (1997), “Epidemiological and offspring analyses of developmental speech disorders using data from the Colorado Adoption Project”, J. Speech Lang. Hear. Res. 40: 778-791.

Fisher, S. E. (2006), “Tangled webs: tracing the connections between genes and cognition”, Cognition 101: 270-297.

Fisher, S. E. y Francks, C. (2006), “Genes, cognition and dyslexia: learning to read the genome”, Trends Cogn. Sci. 10: 250-257.

Fisher, S. E., Lai, C. S: y Monaco, A. P. (2003), “Deciphering the genetic basis of speech and language disorders”, Annu. Rev. Neurosci. 26: 57-80.

Fodor, J. A. (1983), The Modularity of Mind. An Essay on Faculty Psychology. Cambridge: MIT Press.

Folstein, S. E. y Mankoski, R. E. (2000), “Chromosome 7q: where autism meets language disorder?”, Am. J. Hum. Genet. 67: 278-281.

Frangiskakis, J. M., Ewart, A. K., Morris, C. A., Mervis, C. B., Bertrand, J., Robinson, B. F., Klein, B. P., Ensing, G. J., Everett, L. A., Green, E. D., Proschel, C., Gutowski, N. J., Noble, M., Atkinson, D. L., Odelberg, S. J. y Keating, M. T. (1996), “LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition”, Cell 86: 59-69.

Goldin-Meadow, S. y Mylander, C. (1990), “Beyond the input given: the child’s role in the acquisition of language”, J. Child Lang. 17: 527-563.

Gopnik, M. (1990), “Feature-blind grammar and dysphasia”, Nature 344: 715.

Gopnik, M. y Crago, M. B. (1991), “Familial aggregation of a developmental language disorder”, Cognition 39: 1-50.

Gottesman, I. I. y Gould, T. D. (2003), “The endophenotype concept in psychiatry: etymology and strategic intentions”, Am. J. Psychiatry 160: 636645.

Gould, T. D. y Gottesman, I. I. (2006), “Psychiatric endophenotypes and the development of valid animal models”, Genes Brain Behav. 5: 113-119.

Grant, S. G., Marshall, M. C., Page, K. L., Cumiskey, M. A. y Armstrong, J. D. (2005), “Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases”, Hum. Mol. Genet. 14: R225-R234

Graybiel, A. M. (1995), “Building action repertoires: memory and learning functions of the basal ganglia”, Curr. Opin. Neurobiol. 5: 733-741.

Grodzinsky, Y. (2000), “The neurology of syntax: Language use without Broca’s area”, Behav. Brain Sci. 23: 1-71.

Hannula-Jouppi, K., Kaminen-Ahola, N., Taipale, M., Eklund, R., Nopola-Hemmi, J., Kaariainen, H. y Kere J. (2005), “The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia”, PLoS Genet. 1: e50.

Hauser, M. D., Chomsky, N. y Fitch, W. T. (2002), “The faculty of language: what is it, who has it, and how did it evolve?”, Science 298: 1569-1579.

Horwitz, B., Rumsey, J. M. y Donohue, B. C. (1998), “Functional connectivity of the angular gyrus in normal reading and dyslexia”, Proc. Natl. Acad. Sci. U.S.A 95: 8939-8944.

Howard, D. y Franklin, S. (1988), Missing the Meaning: A Cognitive Neuropsychological Study of Processing of Words by an Aphasic Patient. Cambridge: MIT Press.

Jablonka, E. y Lamb, M. J. (2005), Evolution in Four Dimensions. Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life. Cambridge: MIT Press.

Joanisse, M. y Seidenberg, M. (1998), “Specific language impairment: a deficit in grammar or processing”, Trends Cogn. Sci. 2: 240-247.

Kaan, E. y Swaab, T. Y. (2002), “The brain circuitry of syntactic comprehension”, Trends Cogn. Sci. 6: 350-356.

Karmiloff-Smith, A. (1998), “Development itself is the key to understanding developmental disorders”, Trends Cogn. Sci. 2: 389-398.

Kaufmann, W. E. y Worley, P. F. (1999), “Neural activity and immediate early gene expression in the cerebral cortex”, Ment. Retard. Dev. Disabil. Res. Rev. 5: 41-50.

Kosik, K. S. (2003), “Beyond phrenology, at last”, Nat. Rev. Neurosci. 4: 234-239.

Kurosawa, H., Goi, K., Inukai, T., Inaba, T., Chang, K.-S., Shinjyo, T., Rakestraw, K. M., Naeve, C. W. y Look, A. T. (1999), “Two candidate downstream target genes for E2A-HLF”, Blood 93: 321-332.

Kwasnicka-Crawford, D. A., Carson, A. R., Roberts, W., Summers, A. M., Rehnstrom, K., Jarvela, I. y Scherer, S. W. (2005), “Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay”, Genomics. 86: 182-194.

Lai, C. S., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F., y Monaco, A. P. (2001), “A novel forkhead-domain gene is mutated in a severe speech and language disorder”, Nature 413: 519-523.

Lammer, E. J., Scholes, T. y Abrams, L. (2001), “Autosomal recessive tetralogy of Fallot, unusual facies, communicating hydrocephalus, and delayed language development: a new syndrome?”, Clin. Dysmorph. 10: 9-13.

Landau, B. y Jackendoff, R. (1993), ““What” and “where” in spatial language and spatial cognition”, Behav. Brain Sci. 16: 217-265.

Leboyer, M., Bellivier, F., Nosten-Bertrand, M., Jouvent, R., Pauls, D. y Mallet, J. (1998), “Psychiatric genetics: search for phenotypes”, Trends Neurosci. 21: 102-105.

Lefebvre, C. (1998), Creole Genesis and the Acquisition of Grammar. Cambridge: Cambridge University Press.

Leonard, L. B. (1991), “Specific language impairment as a clinical category”, Lang. Speech Hear. Serv. Schools 22: 66-68.

Leonard, L. B. (2002), Children with Specific Language Impairment. Boston: MIT Press.

Lichtenberger, L. y Bellugi, U. (1998), “The intersection of spatial cognition and language in Williams Syndrome”, Soc. Cognit. Neurosci. Abstr. 80: 68.

Lieberman, P. (2002), “On the nature and evolution of the neural bases of human language”, Am. J. Phys. Anthropol. 45: 36-62.

Liégeois F, Baldeweg T, Connelly A, Gadian DG, Mishkin M. y Vargha-Khadem, F. (2003), “Language fMRI abnormalities associated with FOXP2 gene mutation”, Nat. Neurosci. 6:1230-1237.

Locke, J. L. (1983), Phonological Acquisition and Change. New York: Academic Press.

Londin, E. R., Meng, H. y Gruen, J. R. (2003), “A transcription map of the 6p22.3 reading disability locus identifying candidate genes”, BMC Genomics 4: 25.

Longa, V. y Lorenzo, G. (in press), “What about a (really) minimalist theory of language acquisition?”, Linguistics.

Ludlow, C. L. y Dooman, A. G. (1992), “Genetic aspects of idiopathic speech and language disorders”, Otolaryngol. Clin. North Am. 25: 979-994.

Marcus, G. F. (2001), The Algebraic Mind: Integrating Connectionism and Cognitive Science. Cambridge: MIT Press.

Marcus, G. F. (2004), The Birth of the Mind. How a Tiny Number of Genes Creates the Complexities of Human Thought. New York: Basic Books.

Marcus, G. F. (2006), “Cognitive architecture and descent with modification”, Cognition 101: 443-465.

Marcus, G. F. y Fisher, S. E. (2003), “FOXP2 in focus: what can genes tell us about speech and language?”, Trends Cogn. Sci. 7: 257-262.

Markson, L. y Bloom, P. (1997), “Evidence against a dedicated system for word learning in children”, Nature 385: 813-815.

Marsden, C. D. y Obeso, J. A. (1994), “The functions of the basal ganglia and the paradox of sterotaxic surgery in Parkinson’s disease”, Brain 117: 877-897.

Martin, R. C. (2003), “Language processing: functional organization and neuroanatomical basis”, Annu. Rev. Psychol. 54: 55-89.

Mattay, V. y Goldberg, T. E. (2004), “Imaging genetic influences in human brain function”, Curr. Opin. Neurobiol. 14: 239-247.

Meng, H., Smith, S. D., Hager, K., Held, M., Liu, J., Olson, R. K., Pennington, B. F., DeFries, J. C., Gelernter, J., O’Reilly-Pol, T., Somlo, S., Skudlarski, P., Shaywitz, S. E., Shaywitz, B. A., Marchione, K., Wang, Y., Paramasivam, M., LoTurco, J. J., Page, G. P. y Gruen, J. R. (2005), “DCDC2 is associated with reading disability and modulates neuronal development in the brain”, Proc. Nat. Acad. Sci. U.S.A. 102: 17053-17058.

Merzenich, M. M., Jenkins, W. M., Johnston, P., Schreiner, C., Miller, S. L., y Tallal, P. (1996), “Temporal processing deficits of language -learning impaired children ameliorated by training”, Science 271: 76-80.

Mohr, J. P., Pessin, M. S., Finkelstein, S., Funkenstein, H. H., Duncan, G. W. y Davis, K. R. (1978), “Broca aphasia: pathologic and clinical”, Neurology 28: 311-24.

Monchi, O., Petrides, P., Petre, V., Worsley, K. y Dagher, A. (2001), “Wisconsin Card Sorting revisited: distinct neural circuits participating in different stages of the task identified by eventrelated functional magnetic resonance imaging”, J. Neurosci. 21: 7733-7741.

Nazzi, T., Bertoncini, J. y Mehler, J. (1998), “Language discrimination by newborns: toward an understanding of the role of rhythm”, J. Exp. Psychol. Hum. Percept. Perform. 24: 756-766.

Neils, J. y Aram, D. M. (1986), “Family history of children with developmental language disorders”, Percept. Motor. Skill. 63: 655-58.

Newbury, D. F., Bonora, E., Lamb, J. A., Fisher, S. E., Lai, C. S. L., Baird, G., Jannoun, L., Slonims, V., Stott, C. M., Merricks, M. J., Bolton, P. F., Bailey, A. J., Monaco, A. P. e International Molecular Genetic Study of Autism Consortium (2002), “FOXP2 is not a major susceptibility gene for autism or specific language impairment”, Am. J. Hum. Genet. 70: 1318-1327.

Newbury, D. F., Bishop, D. V. y Monaco, A. P. (2005), “Genetic influences on language impairment and phonological short-term memory”, Trends Cogn. Sci. 9: 528-534.

Newmeyer, F. J. (1997), “Genetic dysphasia and linguistic theory”, J. Neurolinguistics 10: 47-73.

Nobre, A. C. y Plunkettt, K. (1997), “The neural system of language: structure and development”, Curr. Opin. Neurobiol. 7: 262-266.

Nopola-Hemmi, J., Myllyluoma, B., Haltia, T., Taipale, M., Ollikainen, V., Ahonen, T., Voutilainen, A., Kere, J. y Widen, E. (2001), “A dominant gene for developmental dyslexia on chromosome 3”, J. Med. Genet. 38: 658-664.

Norbury CF. (1995), “Barking up the wrong tree? Lexical ambiguity resolution in children with language impairments and autistic spectrum disorders”, J. Exp. Child Psychol. 90: 142-171.

Olson, R. K., Forsberg, H. y Wise, B. (1994), “Genes, environment, and the development of orthographic skills”, in V. W. Berninger (ed.), The Varieties of Orthographic Knowledge, I: Theoretical and Developmental Issues. Dordrecht: Kluwer, pp. 27-71.

Oyama, S. (2000), The Ontogeny of Information. Developmental Systems and Evolution. Durham: Duke University Press.

Paracchini, S., Thomas, A., Castro, S., Lai, C., Paramasivam, M., Wang, Y., Keating, B. J., Taylor, J. M., Hacking, D. F., Scerri, T., Francks, C., Richardson, A. J., Wade-Martins, R., Stein, J. F., Knight, J. C., Copp, A. J., Loturco, J. y Monaco, A. P. (2006), “The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration”, Hum. Mol. Genet. 15: 1659-1666.

Plomin, R., Owen, M. J. y McGuffin, P. (1994), “The genetic basis of complex human behaviors”, Science 264: 1733-1739.

Pocklington, A. J., Cumiskey, M., Armstrong, J. D. y Grant, S. G. (2006), “The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour”, Mol. Syst. Biol. 2: 2006.0023

Prasad, C., Prasad, A. N., Chodirker, B. N., Lee, C., Dawson, A. K., Jocelyn, L. J. y Chudley, A. E. (2000), “Genetic evaluation of pervasive developmental disorders: the terminal 22q13 deletion syndrome may represent a recognizable phenotype”, Clin. Genet. 57: 103-109.

Pullum, G. K. y Scholz, B. C. (2002), “Empirical assessment of stimulus poverty arguments”, The Linguistic Review 19: 9-50.

Purvis, K. L. y Tannock, R. (1997), “Language abilities in children with attention deficit hyperactivity disorder, reading disabilities, and normal controls”, J. Abnorm. Child Psychol. 25: 133-144.

Ramus, F. (2006), “Genes, brain, and cognition: A roadmap for the cognitive scientist”, Cognition 101: 247-269.

Rapin, I. y Allen, D. A. (1983), “Developmental language disorders: Nosologic considerations”, in U. Kirk (ed.), Neuropsychology of Language, Reading and Spelling. New York: Academic Press, pp. 155-184.

Roll, P., Rudolf, G., Pereira, S., Royer, B., Scheffer, I. E., Massacrier, A., Valenti, M. P., Roeckel-Trevisiol, N., Jamali, S., Beclin, C., Seegmuller, C., Metz-Lutz, M. N., Lemainque, A., Delepine, M., Caloustian, C., de Saint Martin, A., Bruneau, N., Depetris, D., Mattei, M. G., Flori, E., Robaglia-Schlupp, A., Levy, N., Neubauer, B. A., Ravid, R., Marescaux, C., Berkovic, S. F., Hirsch, E., Lathrop, M., Cau, P. y Szepetowski, P. (2006), “SRPX2 mutations in disorders of language cortex and cognition”, Hum. Mol. Genet. 15: 1195-1207.

Rutter, M. y Mawhood, L. (1991), “The long-term psychosocial sequelae of specific developmental disorders of speech and language”, in M. Rutter y P. Casaer (eds.), Biological Risk Factors For Psychosocial Disorders. Cambridge: Cambridge University Press, pp. 233-259.

Scerif, G. y Karmiloff-Smith, A. (2005), “The dawn of cognitive genetics? Crucial developmental and caveats”, Trends Cogn. Sci. 9: 126-135.

Scheffer, I. E., Jones, L., Pozzebon, M., Howell, R. A., Saling, M. M. y Berkovic, S. F. (1995), “Autosomal dominant rolandic epilepsy and speech dyspraxia: a new syndrome with anticipation”, Ann. Neurol. 38: 633-642.

Schwartz, M. F., Linebarger, M. C., Saffran, E. M. y Pate, D. C. (1987), “Syntactic transparency and sentence interpretation in aphasia”, Lang. Cogn. Process. 2: 85-113.

Selnes, O. A., Knopman, D. S., Niccum, N., Rubens, A. B. y Larson, D. (1983), “Computed tomographic scan correlates of auditory comprehension deficits in aphasia: a prospective recovery study”, Ann. Neurol. 13: 558-566.

Shapiro, L. P., Gordon, B., Hack, N., y Killackey, J. (1993), “Verb-argument structure processing in complex sentences in Broca’s and Wernicke’s aphasia”, Brain Lang. 45: 423-447.

Shaywitz, S. E. (1998), “Dyslexia”, N. Engl. J. Med. 338: 307-312.

Shaywitz, B. A., Fletcher, J. y Shaywitz, S. E. (1995), “Defining and classifying learning disabilities and attention-deficit/hyperactivity disorder”, J. Child Neurol. 10: S50-S57.

Shaywitz, S. E., Shaywitz, B. A., Pugh, K. R., Fulbright, R. K., Constable, R. T., Mencl, W. E., Shankweiler, D. P., Liberman, A. M., Skudlarski, P., Fletcher, J. M., Katz, L., Marchione, K. E., Lacadie, C., Gatenby, C. y Gore, J. C. (1998), “Functional disruption in the organization of the brain for reading in dyslexia”, Proc. Nat. Acad. Sci. U.S.A. 95: 2636-2641.

Shaywitz, B. A., Shaywitz, S. E., Pugh, K. R., Mencl, W. E., Fulbright, R. K., Skudlarski, P., Constable, R. T., Marchione, K. E., Fletcher, J. M., Lyon, G. R. y Gore, J. C. (2002), “Disruption of posterior brain systems for reading in children with developmental dyslexia”, Biol. Psychiatry 52: 101-110.

Shriberg, L. D. y Austin, D. (1998), “Comorbidity of speech-language disorder: Implications for a phenotype marker for speech delay”, in R. Paul (ed.), Exploring the Speech/Language Connection. Baltimore: Brookes, pp. 73-118.

Shriberg, L. D., Tomblin, J. B. y McSweeny, J. L. (1999), “Prevalence of speech delay in 6-year-old children and comorbidity with language impairment”, J. Speech Lang. Hear. Res. 42: 1461-1481.

Shu, W., Yang, H., Zhang, L., Lu, M. M. y Morrisey, E. E. (2001), “Characterization of a new subfamily of wingedhelix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors”, J. Biol. Chem. 276: 2748827497.

Smith, N. (2002), Language, Bananas, and Bonobos: Linguistic Problems, Puzzles, and Polemics. Oxford: Oxford University Press.

Smith, S. D., Gilger, J. W. y Pennington, B. F. (1996), “Dyslexia and other specific learning disorders”, in D. L. Rimoin, J. M. Connor y R. E. Pyeritz (eds.), Principles and Practice of Medical Genetics. New York: Churchill Livingstone, pp. 1767-1789.

Stein, C. M., Schick, J. H., Taylor, H. G., Shriberg, L. D., Millard, C., Kundtz-Kluge, A., Russo, K., Minich, N., Hansen, A., Freebairn, L. A., Elston, R. C., Lewis, B. A. e Iyengar, S. K. (2004), “Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading”, Am. J. Hum. Genet. 74: 283-297.

Stein, C. M., Millard, C., Kluge, A., Miscimarra, L. E., Cartier, K. C., Freebairn, L. A., Hansen, A. J., Shriberg, L. D., Taylor, H. G., Lewis, B. A. e Iyengar, S. K. (2006), “Speech sound disorder influenced by a locus in 15q14 region”, Behav. Genet. 36: 858-868.

Stromswold, K. (1998), “Genetics of spoken language disorders”, Hum. Biol. 70: 293-320.

Sundaresan, V., Roberts, I., Bateman, A., Bankier, A., Sheppard, M., Hobbs, C., Xiong, J., Minna, J., Latif, F., Lerman, M. y Rabbitts, P. (1998), “The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression”, Mol. Cell. Neurosci. 11: 29-35.

Tager-Flusberg, H. (2006), “Defining language phenotypes in autism”, Clin. Neurosci. Res. 6: 219-224.

Tager-Flusberg, H. y Joseph, R. M. (2003), “Identifying neurocognitive phenotypes in autism”, Philos. Trans. R. Soc. B 358: 303-314.

Taipale, M., Kaminen, N., Nopola-Hemmi, J., Haltia, T., Myllyluoma, B., Lyytinen, H., Muller, K., Kaaranen, M., Lindsberg, P. J., Hannula-Jouppi, K. y Kere, J. (2003), “A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain”, Proc. Natl. Acad. Sci. U.S.A. 100: 11553-11558.

Tallal, P., Townsend, J., Curtiss, S. y Wulfeck, B. (1991a), “Phenotypic profiles of language-impaired children based on genetic/family history”, Brain Lang. 41:81-95.

Tallal, P., Sainburg, R. y Jernigan, T. (1991b), “The neuropathology of developmental dysphasia: Behavioral, morphological, and physiological evidence for a pervasive temporal processing disorder”, Read. Writ. 3: 363-377.

Tallal, P., Miller, S. L., Bedi, G., Byma, G., Wang, X., Nagarajan, S. S., Schreiner, C., Jenkins, W. M. y Merzenich, M. M. (1996), “Language comprehension in language-learning impaired children improved with acoustically modified speech”, Science 271: 81-83.

Temple, E., Poldrack, R. A., Protopapas, A., Nagarajan, S., Salz, T., Tallal, P., Merzenich, M. M. y Gabrieli, J. D. E. (2000), “Disruption of the neural response to rapid acoustic stimuli in dyslexia: evidence from functional MRI”, Proc. Nat. Acad. Sci. U.S.A. 97: 13907-13912.

Temple, E., Deutsch, G. K., Poldrack, R. A., Miller, S. L., Tallal, P., Merzenich, M. M. y Gabrieli, J. D. E. (2003), “Neural deficits in children with dyslexia ameliorated by behavioral remediation: evidence from functional MRI”, Proc. Nat. Acad. Sci. U.S.A. 100: 2860-2865.

Tomblin, J. B. (1989), “Familial concentration of developmental language impairment”, J. Speech Hear. Disord. 54: 287-295.

Tomblin, J. B. y Buckwalter, P. R. (1998), “Heritability of poor language achievement among twins”, J. Speech Lang. Hear. Res. 41: 188-199.

Van den Eynde, B. J., Gaugler, B., Probst-Kepper, M., Michaux, L., Devuyst, O., Lorge, F., Weynants, P. y Boon, T. (1999), “A new antigen recognized by cytolytic T lymphocytes on a human kidney tumour results from reverse strand transcription”, J. Exp. Med. 190: 1793-1800.

Van der Lely, H., Rosen, S. y McClelland, A. (1998), “Evidence for a grammarspecific deficit in children”, Curr. Biol. 8: 1253-1258.

Vargha-Khadem, F., Watkins, K. E., Alcock, K. J., Fletcher, P. y Passingham, R. E. (1995), “Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder”, Proc. Natl. Acad. Sci. U.S.A. 92: 930-933.

Vargha-Khadem, F., Watkins, K. E., Price, C. J., Ashburner, J., Alcock, K. J., Connelly, A., Frackowiak, R. S. J., Friston, K. J., Pembrey, M. E., Mishkin, M., Gadian, D. G. y Passingham, R. E. (1998), “Neural basis of an inherited speech and language disorder”, Proc. Nat. Acad. Sci. U.S.A. 95: 12695-12700.

Vargha-Khadem, F., Gadian, D. G., Copp, A. y Mishkin, M. (2005), “FOXP2 and the neuroanatomy of speech and language”, Nat. Rev. Neurosci. 6: 131-138.

Wassink, T. H., Piven, J., Vieland, V. J., Huang, J., Swiderski, R. E., Pietila, J., Braun, T., Beck, G., Folstein, S. E., Haines, J. L. y Sheffield, V. C. (2001), “Evidence supporting WNT2 as an autism susceptibility gene”, Am. J. Med. Genet. 105: 406-413.

Watkins, K. E., Dronkers, N. F. y Vargha-Khadem, F. (2002a), “Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia”, Brain 125: 452-64.

Watkins, K. E., Vargha-Khadem, F., Ashburner, J., Passingham, R. E., Connelly, A., Friston, K. J., Frackiwiak, R. S. J., Miskin, M. y Gadian, D. G. (2002b), “MRI analysis of an inherited speech and language disorder: structural brain abnormalities”, Brain 125: 465- 478.

Werker, J. F. y Tees, R. C. (1984), “Cross-language speech perception: evidence for perceptual reorganisation during the first year of life”, Infant Behav. Dev. 7: 49-63.

Ziff, E. B. (1997), “Enlightening the postsynaptic density”, Neuron 19: 1163-1174.


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